Methylene Chloride


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Introduction

Methylene chloride, also known as dichloromethane, is a colorless liquid that has a mild sweet odor, evaporates very quickly, and will not easily burn. It is widely used as an industrial solvent and as a paint stripper. It can also be found in certain aerosol and pesticide products and is used in the manufacture of photographic film. Methylene chloride does not appear to occur naturally in the environment. It is made from methane gas or wood alcohol. Most of the methylene chloride released to the environment results from its use as an end product by various industries and the use of aerosol products and paint removers in the home.

Structural diagram: National Institutes of Health


Fate & Transport

Methylene chloride is mainly released to the environment in air and to a lesser extent in water and soil, due to industrial and consumer uses. Many chemical waste sites, including NPL sites, contain methylene chloride and these might act as additional sources of environmental contamination through spills, leaks, or evaporation. Because methylene chloride evaporates readily, most of it is released into the air. In air, it is broken down by sunlight and by reaction with other chemicals present in the air. About half of the methylene chloride disappears from air in 53-127 days. Although methylene chloride does not dissolve easily in water, small amounts may be found in some drinking water. Methylene chloride that is present in water is broken down slowly by reactions with other chemicals or by bacteria. Over 90 percent of the methylene chloride in the environment changes to carbon dioxide, which is non-toxic. It takes about 1 to 6 days for half the methylene chloride to break down in water. When methylene chloride is spilled on land, it attaches loosely to nearby surface soil particles. It moves from the soil into the air. Some may also move into groundwater. We do not know how long it remains in soil. We do not expect methylene chloride to build up in plants or animals.

Exposure Pathways

You may be exposed to methylene chloride in air, water, food, or from consumer products. Because methylene chloride evaporates easily, the greatest potential for exposure is when you breathe vapors of contaminated air. Background levels in air are usually at less than 1 part methylene chloride per billion parts (ppb) of air. Methylene chloride has been found in some urban air and at some hazardous waste sites at average concentrations of 11 ppb of air. The average daily intake of methylene chloride from outdoor air in three United States cities ranges from 33 to 309 micrograms per day (ug/day). Contact with consumer products such as paint strippers or aerosol cans that contain methylene chloride is another frequent source of exposure. Exposure occurs as a result of breathing the vapors given off by the product or from direct contact of the liquid material with the skin. Air concentrations resulting from the use of consumer products containing methylene chloride usually ranges from 1 to 23 ppb. The highest and most frequent exposures to methylene chloride usually occur in workplaces where the chemical is used. People who work in these places can breathe in the chemical or it may come in contact with their skin. Concentrations ranging from 1 to 1,000 parts methylene chloride per million parts (ppm; 1 ppm is 1,000 times more than 1 ppb) of air have been detected in general work areas, while higher concentrations (1,400 ppm) have been detected in samples in the breathing zone of some workers. The National Institute for Occupational Safety and Health (NIOSH) estimated that 1,000,000 workers may be exposed to methylene chloride. An average of 68 ppb of methylene chloride in surface water and 98 ppb methylene chloride in groundwater have been found at some hazardous waste sites. Less than 1 ppb has been found in most drinking water analyzed. We expect exposure from water and food to be low because very little methylene chloride has been detected in these sources.

Metabolism

Methylene chloride may enter your body when you breathe vapors of contaminated air. It may also enter your body if you drink water from contaminated wells, or it may enter if your skin comes in contact with it. Because methylene chloride evaporates into air rapidly, exposure by breathing is the most likely source of exposure at hazardous waste sites, in the home, and in the workplace. When you breathe in methylene chloride, over 70% of it enters your bloodstream and quickly spreads throughout your body, with most of it going to the liver, kidney, brain, lungs, and fatty tissue. Increased physical activity or an increased amount of body fat tend to increase the amount of methylene chloride that remains or accumulates in your body tissue. About half of the methylene chloride in the blood leaves within 40 minutes. Some of the methylene chloride is broken down into other chemicals, including carbon monoxide (CO). Carbon monoxide is also toxic because it combines with hemoglobin to form carboxyhemoglobin (CO-Hb). Unchanged methylene chloride and its breakdown products are removed from your body mainly in the air you breathe out. Small amounts leave in your urine. This usually occurs within 48 hours after exposure. Although the rate of uptake through the skin and stomach have not been measured, uptake is likely to be fast.

Health Effects

If you breathe methylene chloride (300 ppm) or greater for short periods of time (e.g., 3-4 hours), you may not be able to hear faint sounds and your vision may be slightly impaired. If you breathe large amounts (800 ppm) you may not be able to react fast, remain steady, or perform tasks requiring precise hand movements. You may experience dizziness, nausea, tingling or numbness of the fingers and toes, and drunkenness if you breathe methylene chloride for a longer time. In most cases, effects disappear after exposure ends. Studies in animals suggest that exposure to higher concentrations (greater than 1,000 ppm) can lead to unconsciousness and death.

Breathing methylene chloride also causes changes in the liver and kidney in animals, but similar effects have not been observed in humans. Studies in animals suggest that breathing methylene chloride does not cause birth defects or affect reproduction, even at high concentrations. Animal studies indicate that should you be exposed to vapors of methylene chloride in air, the vapors may irritate your eyes and affect your cornea. One study reported these effects at concentrations of 490 ppm; however the effects usually disappeared within a few days.

Methylene chloride has not been shown to cause cancer in humans exposed to vapors in the workplace. However, breathing high concentrations of methylene chloride for long periods of time did cause cancer in mice. The International Agency for Research on Cancer has determined that methylene chloride is possibly carcinogenic to humans. No information was found regarding the effects of methylene chloride in humans after oral exposure. Methylene chloride has caused death in rats following oral exposure to large amounts over a short period of time.

No information was found regarding the effects of methylene chloride in humans after skin exposure or direct contact with the eyes. In rabbits, effects were observed on the eyes (i.e., cornea), but they were reversible within a few days.

People can smell methylene chloride at about 200 ppm in air. Because people differ in their ability to smell various chemicals, odors may not be helpful in avoiding overexposure.

Information excerpted from:

Toxicological Profile for Methylene Chloride October 1991 Update

Agency for Toxic Substances and Disease Registry
U.S. Dept. of Health and Human Services